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Kittleson MD, Meurs KM, Harris SP. The genetic basis of hypertrophic cardiomyopathy in cats and humans. J Vet Cardiol. 2015;17 Suppl 1:S53–73. Epub 2016/01/19. pmid:26776594; PubMed Central PMCID: PMC5909964. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009;25(16):2078–9. Epub 2009/06/10. pmid:19505943; PubMed Central PMCID: PMC2723002.

Nominations Announced for the 28th Huading Awards – "The Global Film Satisfaction Survey Release Ceremony" ". Tyler Morning Telegraph. 23 October 2020. Archived from the original on 15 November 2020 . Retrieved 14 November 2020. To the left of the figure panels, constraint groups are labeled with pLI ranges shown below in braces. Below the pLI ranges are the number of genes found in each constraint group. SNV values show the total number of SNVs of a particular impact that belong to each constraint group. (a) Observed percentage differences from expected values for per kb SNV density. Light colored rectangles represent the 95% confidence intervals for the expected values. Confidence intervals were calculated using 10,000 permutations (methods). (b) The percentage of SNVs of different impacts and constraint groups across various MAF intervals. (c) Observed percentage differences from expected values for the fraction of SNVs in a singleton state (allele count of 1). Light colored rectangles represent the 95% confidence intervals for the expected values, generated from 10,000 permutations. (d) Pairwise SNV count contrasts between gene constraint groups and SNVs of the same impact. “*” indicates a p-value < 0.05 and “**” indicates a p-value < 0.001. (e) Pairwise singleton count contrasts between gene constraint groups and SNVs of the same impact. Asterisks above odds ratio values indicate the same values as (d). Criscitiello, Alexa (4 January 2018). "Andrew Lloyd Webber Pens New Tune for CATS Film Adaptation". BroadwayWorld.com. Archived from the original on 6 January 2018 . Retrieved 21 February 2019. In the veterinary clinic, the practice of genomic medicine is impending [ 1]. With actionable genetic information in hand, companion animal therapeutic interventions are feasible, including treatment of animal patients prior to, or to prevent the appearance of, more severe symptoms and allow therapeutic administration of drugs with higher efficacy and fewer side effects. Genomic information can also alert veterinarians to imminent disease risks for diagnostic consideration. Each of these applications could significantly enhance veterinary medicine, however, none are currently in practice. As in human medicine, formidable challenges exist for the implementation of genomic-based medicine, including accurate annotation of the genome and databases of genetic variation from well-phenotyped individuals that include both single nucleotide variant (SNV) and structural variant (SV) discovery and annotation [ 2– 4]. Targeted individual companion animal genome information is becoming more readily available, cost effective, and tentatively linked to the actionable phenotypes via direct-to-consumer DNA testing. Thus correct interpretation of DNA variants is of the utmost importance for communicating findings to clinicians practicing companion animal genomic medicine [ 5]. Ontiveros ES, Ueda Y, Harris SP, Stern JA, 99 Lives Consortium. Precision medicine validation: identifying the MYBPC 3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy. Journal of feline medicine and surgery. 2018:1098612X18816460.Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, et al. Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell. 2013;154(3):691–703. Epub 2013/07/31. pmid:23890820; PubMed Central PMCID: PMC3732391. Bradshaw, Peter (19 December 2019). "Cats review – a purr-fectly dreadful hairball of woe". The Guardian. Archived from the original on 19 December 2019 . Retrieved 19 December 2019. In January 2018, Hooper and Working Title began officially casting for the film, while looking into the technical aspect of whether the film would be entirely live-action or computer generated, with Lloyd Webber announcing he would be writing a new song for the film adaptation. [31] On 24 October 2019, it was announced that the new song was titled " Beautiful Ghosts", written by Lloyd Webber and Taylor Swift. [32] The song was sung by Francesca Hayward, followed later in a reprise by Judi Dench, with a credits version sung by Swift. [33] The version sung by Swift was released on 15 November 2019. [34] Casting [ edit ] Zerbino DR, Achuthan P, Akanni W, Amode MR, Barrell D, Bhai J, et al. Ensembl 2018. Nucleic Acids Res. 2018;46(D1):D754–D61. Epub 2017/11/21. pmid:29155950; PubMed Central PMCID: PMC5753206. Domestic cats, while a great source of comfort to millions, are the largest carriers of toxoplasmosis that cause zoonosis, a study published in Nature Communications shows.

Hammond, Pete (19 December 2019). " 'Cats' Review: Full Of Memorable Performances From Jennifer Hudson To Taylor Swift, This Adaptation Hits The Right Notes". Deadline. Archived from the original on 19 December 2019 . Retrieved 19 December 2019. Lam ET, Hastie A, Lin C, Ehrlich D, Das SK, Austin MD, et al. Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly. Nature biotechnology. 2012;30(8):771. pmid:22797562 Stolworthy, Jacob (22 December 2019). "Huge Cats mistake revealed in another embarrassing blunder for film". The Independent. Archived from the original on 25 December 2019 . Retrieved 25 December 2019. Universal Pictures (17 July 2019). CATS – A Look Inside. Archived from the original on 19 July 2019 . Retrieved 19 July 2019. Music for the film was composed by Andrew Lloyd Webber with contributions from producer Greg Wells, who was initially brought in after production in mid-2019. [52] The recordings were created partly at Abbey Road Studios with contributions from the London Symphony Orchestra. [52] Wells also played a number of instruments on the music himself, including the drums, pipe organ, bass guitar and Abbey Road's fabled Mrs Mills piano, used in Beatles songs such as "Penny Lane" and "With a Little Help from My Friends". [52]

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D'Alessandro, Anthony (25 September 2018). " 'Cats' Cast Grows: Tom Hooper-Directed Musical Adds Laurie Davidson". Deadline. Archived from the original on 26 September 2018 . Retrieved 21 February 2019. SNV minor allele frequency (MAF) distributions were compared across each constraint group. MAFs for synonymous SNVs were similarly distributed in all constraint groups. Conversely, the distribution of nonsynonymous SNVs increasingly skewed toward lower MAFs under stronger levels of constraint. For example, 25.5% of LoF SNVs in genes under weak constraint have a MAF < 1%, whereas 35.9% of LoF SNVs in genes under strong constraint have a MAF < 1% ( Fig 2B). To determine whether these shifts in MAFs were significant, the fraction of SNVs in a singleton state were compared to expected levels based on random assignment of singleton states. Singleton states of SNVs were significantly enriched for nonsynonymous SNVs with enrichment levels increasing under stronger constraint, indicating many SNVs with functional impacts in genes under constraint are likely rare ( Fig 2C). Together, these results show a significant association between selection in human genes and SNV accumulation in cats, suggesting selection pressure within cats and humans is similar across orthologous genes. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, et al. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature. 2004;432(7018):775–9. Epub 2004/12/14. pmid:15592418. Hamlet, Isaac (18 February 2020). "Why one of the Midwest's most cutting-edge theaters is screening 2019's biggest box-office bomb". Iowa City Press-Citizen . Retrieved 26 February 2020. Teng H, Zhang Y, Shi C, Mao F, Cai W, Lu L, et al. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. Mol Biol Evol. 2017;34(9):2214–28. Epub 2017/05/10. pmid:28482038; PubMed Central PMCID: PMC5850741.

Figures

Taylor Swift On Side-Stepping Into Acting, Owning What You Make & Loving The "Weirdness" Of Cats". British Vogue. 2 December 2019. Archived from the original on 2 December 2019 . Retrieved 2 December 2019. In February 2016, it was reported that Tom Hooper was in negotiations to direct the film, and was considering actresses, including Suki Waterhouse, to star. [29] In May 2016, Hooper was confirmed as director. [30] Setoodeh, Ramin (16 December 2019). "Taylor Swift Reveals How Her Dad Inspired a Psychedelic Scene in 'Cats' (EXCLUSIVE)". Variety. Archived from the original on 17 December 2019 . Retrieved 17 December 2019. Chang, Justin (18 December 2019). "Review: 'Cats' is a horror — and an occasional hoot". Los Angeles Times. Archived from the original on 19 December 2019 . Retrieved 19 December 2019. Lang, Brent (3 December 2013). " 'Cats' Movie May Happen, Lord Andrew Lloyd Webber Says". TheWrap. Archived from the original on 20 July 2018 . Retrieved 21 February 2019.

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