Lasofoxifene is new third-generation SERM that binds to both estrogen receptor types and is currently not approved for use by the FDA.

These products literally damage the vaginal mucosa and microbiome and that is the 'result'—[desquamated] inflamed cells and dead bacteria and mucus.And, it’s important to point out, your pelvic floor muscles help support the vagina and surrounding structures, but they are not what make up the vaginal walls. More than half of menopausal women are concerned about the symptoms of VVA, such as dryness, burning, itching, vaginal discomfort, pain and burning when urinating, dyspareunia, and spotting during intercourse.

Intravaginal practices and risk of bacterial vaginosis and candidiasis infection among a cohort of women in the United States. The levels of estradiol and testosterone in the serum may have minimal increases, without clinical significance presumably because of local inactivation. Streicher said it seems to cause the epithelial tissue—or the top layer of tissue—in the vagina to slough off.Vaginal rings are inserted for up to 90 days and can be independently installed and removed by the patient. The diagnosis is confirmed by vaginal examination and colposcopy, wherein atrophic epithelium and thin, pale, and easily traumatized petechial hemorrhages can be detected. All these manifestations significantly reduce the quality of life and cause discomfort in the sexual sphere. However, clinical observations of the use of this group of low-dose estrogens are limited to 1 year. In a new prospective, randomized, double-blind clinical trial, Labrie et al confirmed the local beneficial effect of intravaginal DHEA (prasterone) on the symptoms of mild/severe dyspareunia, the most frequent manifestation of genitourinary syndrome in postmenopausal women.

But if you are going to pick one and you really want to try one, the probiotics that seem to show some benefit in studies are ones containing Lactobacillus rhamnosus GR-1. My husband always works late and falls asleep after dinner, I don't think he's interested in me at all right now, but god knows how horny I am.Our Annie Care Natural Detox Viginal Gel feature a natural formula with various plant extracts that effectively repairs the uterus and vaginal mucosa, promoting self-cleaning and moisturization. Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile.